General Information of the Compound
Compound ID
CP0434217
Compound Name
(3R,4S)-N-(3,5-bis(trifluoromethyl)benzyl)-1-(cyclohexanecarbonyl)-N-methyl-4-phenylpyrrolidine-3-carboxamide
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Structure
Formula
C28H30F6N2O2
Molecular Weight
540.548
Canonical SMILES
CN(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CN(C[C@@H]1c1ccccc1)C(=O)C1CCCCC1
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InChI
InChI=1S/C28H30F6N2O2/c1-35(15-18-12-21(27(29,30)31)14-22(13-18)28(32,33)34)26(38)24-17-36(25(37)20-10-6-3-7-11-20)16-23(24)19-8-4-2-5-9-19/h2,4-5,8-9,12-14,20,23-24H,3,6-7,10-11,15-17H2,1H3/t23-,24+/m1/s1
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InChIKey
PRGSOEXCXSTEHC-RPWUZVMVSA-N
Physicochemical Property
logP
6.5051
Rotatable Bonds
5
Heavy Atom Count
38
Polar Areas
40.62
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44433784
ChEMBL ID
CHEMBL238210
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.68 nM
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