General Information of the Compound
Compound ID
CP0434151
Compound Name
(2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(5-phenylfuran-2-yl)-1,3,4-thiadiazol-2-yl)methyl)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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Structure
Formula
C25H23ClN2O6S
Molecular Weight
514.987
Canonical SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccc(o2)-c2ccccc2)c1
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InChI
InChI=1S/C25H23ClN2O6S/c26-16-7-6-14(24-23(32)22(31)21(30)19(12-29)34-24)10-15(16)11-20-27-28-25(35-20)18-9-8-17(33-18)13-4-2-1-3-5-13/h1-10,19,21-24,29-32H,11-12H2/t19-,21-,22+,23-,24+/m1/s1
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InChIKey
RGUCICJZAMPSRR-ZXGKGEBGSA-N
Physicochemical Property
logP
3.2242
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
129.07
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46228980
SID: 104174901
ChEMBL ID
CHEMBL590992
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02415, Sodium/glucose cotransporter 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 10.6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10.6 nM