General Information of the Compound
Compound ID
CP0433439
Compound Name
3-(3,3-dimethylbutyl)-5-[2-oxo-2-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]ethyl]-2-(2-pyrazol-1-ylphenyl)-1,3-thiazolidin-4-one
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Structure
Formula
C33H40N6O3S
Molecular Weight
600.789
Canonical SMILES
CC(C)(C)CCN1C(SC(CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1-n1cccn1
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InChI
InChI=1S/C33H40N6O3S/c1-33(2,3)15-20-37-30(41)28(43-31(37)25-10-5-7-12-27(25)39-17-8-16-34-39)21-29(40)36-18-13-24(14-19-36)38-22-23-9-4-6-11-26(23)35-32(38)42/h4-12,16-17,24,28,31H,13-15,18-22H2,1-3H3,(H,35,42)
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InChIKey
IJVMYLQZKRDFKU-UHFFFAOYSA-N
Physicochemical Property
logP
5.6799
Rotatable Bonds
7
Heavy Atom Count
43
Polar Areas
90.78
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59554885
ChEMBL ID
CHEMBL3114479
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
IC50 = 62 nM
   TI
   LI
   LO
   TS
2
Ki = 40 nM
   TI
   LI
   LO
   TS