General Information of the Compound
Compound ID
CP0431298
Compound Name
1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylpyrazol-3-yl)-6,7,9,9a-tetrahydro-4H-pyrazino[1,2-a]pyrazine-8-carboxamide
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Structure
Formula
C26H26N6O3
Molecular Weight
470.533
Canonical SMILES
O=C(Nc1ccnn1-c1ccccc1)N1CCN2CC(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1
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InChI
InChI=1S/C26H26N6O3/c33-24-17-29-13-14-30(26(35)28-23-11-12-27-32(23)19-9-5-2-6-10-19)16-22(29)25(34)31(24)21-15-20(21)18-7-3-1-4-8-18/h1-12,20-22H,13-17H2,(H,28,35)/t20-,21+,22?/m1/s1
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InChIKey
ORMFQNXSYVRSHS-LKXRKSRJSA-N
Physicochemical Property
logP
2.3153
Rotatable Bonds
4
Heavy Atom Count
35
Polar Areas
90.78
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56680280
ChEMBL ID
CHEMBL1807235
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  1
1
IC50 = 5100 nM
   TI
   LI
   LO
   TS