General Information of the Compound
Compound ID
CP0430993
Compound Name
N,4-dimethyl-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)benzamide
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Structure
Formula
C17H15N3OS
Molecular Weight
309.394
Canonical SMILES
CN(C(=O)c1ccc(C)cc1)c1nc(cs1)-c1ccncc1
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InChI
InChI=1S/C17H15N3OS/c1-12-3-5-14(6-4-12)16(21)20(2)17-19-15(11-22-17)13-7-9-18-10-8-13/h3-11H,1-2H3
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InChIKey
CPYNENNNFDPGKD-UHFFFAOYSA-N
Physicochemical Property
logP
3.79012
Rotatable Bonds
3
Heavy Atom Count
22
Polar Areas
46.09
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16661405
SID: 26521420
ChEMBL ID
CHEMBL579225
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01994, Metabotropic glutamate receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 83 nM
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