General Information of the Compound
Compound ID
CP0430793
Compound Name
5-[(4-Biphenylmethyl)carbonyl]amino-8-(3-phenylpropyl)-2-(2-furyl)-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
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Structure
Formula
C33H27N7O2
Molecular Weight
553.626
Canonical SMILES
O=C(Cc1ccc(cc1)-c1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(nn12)-c1ccco1
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InChI
InChI=1S/C33H27N7O2/c41-29(21-24-15-17-26(18-16-24)25-12-5-2-6-13-25)34-33-36-30-27(32-35-31(38-40(32)33)28-14-8-20-42-28)22-39(37-30)19-7-11-23-9-3-1-4-10-23/h1-6,8-10,12-18,20,22H,7,11,19,21H2,(H,34,36,37,41)
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InChIKey
FPCTUKFYWXDOAK-UHFFFAOYSA-N
Physicochemical Property
logP
6.215
Rotatable Bonds
9
Heavy Atom Count
42
Polar Areas
103.14
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45482092
ChEMBL ID
CHEMBL572602
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1170 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS