General Information of the Compound
Compound ID
CP0430650
Compound Name
(R)-2-((2-oxo-3,4-dihydroquinolin-1(2H)-yl)methyl)-6,8-dihydrospiro[cyclopenta[g]quinoline-7,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
    Show/Hide
Structure
Formula
C28H22N4O2
Molecular Weight
446.51
Canonical SMILES
O=C1Nc2ncccc2[C@]11Cc2cc3ccc(CN4C(=O)CCc5ccccc45)nc3cc2C1
    Show/Hide
InChI
InChI=1S/C28H22N4O2/c33-25-10-8-17-4-1-2-6-24(17)32(25)16-21-9-7-18-12-19-14-28(15-20(19)13-23(18)30-21)22-5-3-11-29-26(22)31-27(28)34/h1-7,9,11-13H,8,10,14-16H2,(H,29,31,34)/t28-/m1/s1
    Show/Hide
InChIKey
GCWWLFCJNPWAEP-MUUNZHRXSA-N
Physicochemical Property
logP
4.0979
Rotatable Bonds
2
Heavy Atom Count
34
Polar Areas
75.19
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 46885134
ChEMBL ID
CHEMBL1090847
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
IC50 = 4.7 nM
   TI
   LI
   LO
   TS
2
IC50 = 81 nM
   TI
   LI
   LO
   TS
3
Ki = 1.4 nM
   TI
   LI
   LO
   TS