Brief Information of the Compound and Protein
Compound Name
(R)-2-((2-oxo-3,4-dihydroquinolin-1(2H)-yl)methyl)-6,8-dihydrospiro[cyclopenta[g]quinoline-7,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
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PubChem ID
CID: 46885134
Canonical SMILES
O=C1Nc2ncccc2[C@]11Cc2cc3ccc(CN4C(=O)CCc5ccccc45)nc3cc2C1
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Compound Formula C28H22N4O2
Compound Structure
Protein Name
Calcitonin gene-related peptide type 1 receptor
Protein Classification
Membrane receptor
>
Family B G protein-coupled receptor
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Peptide receptor (family B GPCR)
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Calcitonin-like receptor
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Calcitonin gene-related peptide receptor
Uniprot ID
Q16602
Gene Name
CALCRL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
IC50 = 4.7 nM
   TI
   LI
   LO
   TS
2
IC50 = 81 nM
   TI
   LI
   LO
   TS
3
Ki = 1.4 nM
   TI
   LI
   LO
   TS