General Information of the Compound
Compound ID
CP0430620
Compound Name
1-(2,3-dichlorophenyl)-3-[(2S)-1,4-dioxo-4-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]-1-(4-piperidin-1-ylpiperidin-1-yl)butan-2-yl]urea
    Show/Hide
Structure
Formula
C34H43Cl2N7O4
Molecular Weight
684.669
Canonical SMILES
Clc1cccc(NC(=O)N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)c1Cl
    Show/Hide
InChI
InChI=1S/C34H43Cl2N7O4/c35-26-8-6-10-28(31(26)36)37-33(46)38-29(32(45)42-19-11-24(12-20-42)40-15-4-1-5-16-40)21-30(44)41-17-13-25(14-18-41)43-22-23-7-2-3-9-27(23)39-34(43)47/h2-3,6-10,24-25,29H,1,4-5,11-22H2,(H,39,47)(H2,37,38,46)/t29-/m0/s1
    Show/Hide
InChIKey
PBUPPCADLYJEBN-LJAQVGFWSA-N
Physicochemical Property
logP
5.3892
Rotatable Bonds
7
Heavy Atom Count
47
Polar Areas
117.33
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
47

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 58864368
ChEMBL ID
CHEMBL2018488
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
IC50 = 97 nM
   TI
   LI
   LO
   TS