General Information of the Compound
Compound ID
CP0430329
Compound Name
3-(2,4-Dimethyl-4-phenyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-5-fluoro-benzonitrile
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Structure
Formula
C23H19FN2O
Molecular Weight
358.416
Canonical SMILES
CC1Nc2ccc(cc2C(C)(O1)c1ccccc1)-c1cc(F)cc(c1)C#N
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InChI
InChI=1S/C23H19FN2O/c1-15-26-22-9-8-17(18-10-16(14-25)11-20(24)12-18)13-21(22)23(2,27-15)19-6-4-3-5-7-19/h3-13,15,26H,1-2H3
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InChIKey
JIXOXKZNTPAKSI-UHFFFAOYSA-N
Physicochemical Property
logP
5.41598
Rotatable Bonds
2
Heavy Atom Count
27
Polar Areas
45.05
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 18374557
ChEMBL ID
CHEMBL165215
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  2
1
EC50 = 8.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 24.7 nM
   TI
   LI
   LO
   TS