General Information of the Compound
Compound ID
CP0430159
Compound Name
5-[(2,6-Dichlorobenzyl)carbonyl]amino-8-(2-phenylpropyl)-2-(2-furyl)-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
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Structure
Formula
C27H21Cl2N7O2
Molecular Weight
546.418
Canonical SMILES
Clc1cccc(Cl)c1CC(=O)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(nn12)-c1ccco1
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InChI
InChI=1S/C27H21Cl2N7O2/c28-20-10-4-11-21(29)18(20)15-23(37)30-27-32-24-19(26-31-25(34-36(26)27)22-12-6-14-38-22)16-35(33-24)13-5-9-17-7-2-1-3-8-17/h1-4,6-8,10-12,14,16H,5,9,13,15H2,(H,30,32,33,37)
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InChIKey
SZEMNKQDKREGQR-UHFFFAOYSA-N
Physicochemical Property
logP
5.8548
Rotatable Bonds
8
Heavy Atom Count
38
Polar Areas
103.14
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45482091
ChEMBL ID
CHEMBL578649
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 786 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS