General Information of the Compound
Compound ID
CP0429548
Compound Name
N-[[1-(ethylamino)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
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Structure
Formula
C25H32N6O2
Molecular Weight
448.571
Canonical SMILES
CCNC1(CNC(=O)N2CCC(CC2)c2nc(no2)-c2ccc3ccccc3n2)CCCC1
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InChI
InChI=1S/C25H32N6O2/c1-2-27-25(13-5-6-14-25)17-26-24(32)31-15-11-19(12-16-31)23-29-22(30-33-23)21-10-9-18-7-3-4-8-20(18)28-21/h3-4,7-10,19,27H,2,5-6,11-17H2,1H3,(H,26,32)
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InChIKey
CDBHWBWRISTEBO-UHFFFAOYSA-N
Physicochemical Property
logP
4.0961
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
96.18
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56658050
ChEMBL ID
CHEMBL1822446
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  2
1
IC50 = 46 nM
   TI
   LI
   LO
   TS
2
IC50 = 91 nM
   TI
   LI
   LO
   TS