General Information of the Compound
Compound ID
CP0429452
Compound Name
2-amino-4-[4-(cyclopropylmethoxy)phenyl]-6-(1H-1,2,4-triazol-5-ylmethylsulfanyl)pyridine-3,5-dicarbonitrile
    Show/Hide
Structure
Formula
C20H17N7OS
Molecular Weight
403.471
Canonical SMILES
Nc1nc(SCc2ncn[nH]2)c(C#N)c(-c2ccc(OCC3CC3)cc2)c1C#N
    Show/Hide
InChI
InChI=1S/C20H17N7OS/c21-7-15-18(13-3-5-14(6-4-13)28-9-12-1-2-12)16(8-22)20(26-19(15)23)29-10-17-24-11-25-27-17/h3-6,11-12H,1-2,9-10H2,(H2,23,26)(H,24,25,27)
    Show/Hide
InChIKey
QRCPSGPTOXDURB-UHFFFAOYSA-N
Physicochemical Property
logP
3.27336
Rotatable Bonds
7
Heavy Atom Count
29
Polar Areas
137.29
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 145972065
ChEMBL ID
CHEMBL4215091
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 338 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 51 nM
   TI
   LI
   LO
   TS