General Information of the Compound
Compound ID
CP0423391
Compound Name
2-(5-{5-[(3-Amino-quinolinyl)-methyl]-pyridin-2-yl}-thiophen-2-yl)-2-oxoethyl Ethyl Trithiocarbonate
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Structure
Formula
C24H21N3OS4
Molecular Weight
495.72
Canonical SMILES
CCSC(=S)SCC(=O)c1ccc(s1)-c1ccc(CNc2cnc3ccccc3c2)cn1
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InChI
InChI=1S/C24H21N3OS4/c1-2-30-24(29)31-15-21(28)23-10-9-22(32-23)20-8-7-16(13-26-20)12-25-18-11-17-5-3-4-6-19(17)27-14-18/h3-11,13-14,25H,2,12,15H2,1H3
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InChIKey
KHMNQJIQFPCIRQ-UHFFFAOYSA-N
Physicochemical Property
logP
6.9243
Rotatable Bonds
8
Heavy Atom Count
32
Polar Areas
54.88
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24895117
SID: 53779310
ChEMBL ID
CHEMBL481703
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00991, Histone deacetylase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 555 nM
   TI
   LI
   LO
   TS
Protein ID: PT01213, Histone deacetylase 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 438 nM
   TI
   LI
   LO
   TS