General Information of the Compound
Compound ID
CP0422760
Compound Name
17beta-Hydroxy-11beta-[4-(N-methynonylamino)-phenyl]-17alpha-(1-propinyl)-estra-4,9-dien-3-one
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Structure
Formula
C37H51NO2
Molecular Weight
541.82
Canonical SMILES
CCCCCCCCCN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
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InChI
InChI=1S/C37H51NO2/c1-5-7-8-9-10-11-12-24-38(4)29-16-13-27(14-17-29)33-26-36(3)34(21-23-37(36,40)22-6-2)32-19-15-28-25-30(39)18-20-31(28)35(32)33/h13-14,16-17,25,32-34,40H,5,7-12,15,18-21,23-24,26H2,1-4H3/t32-,33+,34-,36-,37-/m0/s1
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InChIKey
WWMRNGPAVKCFBX-CVXAHBFTSA-N
Physicochemical Property
logP
8.5273
Rotatable Bonds
10
Heavy Atom Count
40
Polar Areas
40.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25231472
SID: 57583401
ChEMBL ID
CHEMBL459203
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 1.4 nM
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