General Information of the Compound
Compound ID
CP0422702
Compound Name
N-[2-[(2S)-2-[2-(cyclopropylamino)-2-oxoacetyl]pyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
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Formula
C21H22N4O4
Molecular Weight
394.431
Canonical SMILES
O=C(CNC(=O)c1ccnc2ccccc12)N1CCC[C@H]1C(=O)C(=O)NC1CC1
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InChI
InChI=1S/C21H22N4O4/c26-18(25-11-3-6-17(25)19(27)21(29)24-13-7-8-13)12-23-20(28)15-9-10-22-16-5-2-1-4-14(15)16/h1-2,4-5,9-10,13,17H,3,6-8,11-12H2,(H,23,28)(H,24,29)/t17-/m0/s1
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InChIKey
UWWNVTQYDDYRFC-KRWDZBQOSA-N
Physicochemical Property
logP
0.8033
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
108.47
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4847764
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01241, Prolyl endopeptidase FAP
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000090 Schneider 2 Drosophila melanogaster (Fruit fly)  1
1
IC50 = 0.64 nM
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