General Information of the Compound
Compound ID
CP0422212
Compound Name
6-(3-Cyano-5-fluoro-phenyl)-4,4-dimethyl-1,4-dihydro-2H-benzo[d][1,3]oxazine-2-carboxylic acid ethyl ester
    Show/Hide
Structure
Formula
C20H19FN2O3
Molecular Weight
354.381
Canonical SMILES
CCOC(=O)C1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
    Show/Hide
InChI
InChI=1S/C20H19FN2O3/c1-4-25-19(24)18-23-17-6-5-13(10-16(17)20(2,3)26-18)14-7-12(11-22)8-15(21)9-14/h5-10,18,23H,4H2,1-3H3
    Show/Hide
InChIKey
SWLNWRPERFZMQP-UHFFFAOYSA-N
Physicochemical Property
logP
3.93078
Rotatable Bonds
3
Heavy Atom Count
26
Polar Areas
71.35
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44378790
ChEMBL ID
CHEMBL165055
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  3
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
IC50 = 158.8 nM
   TI
   LI
   LO
   TS
3
IC50 = 1793 nM
   TI
   LI
   LO
   TS