General Information of the Compound
Compound ID
CP0422170
Compound Name
(1S,2R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-1-(4-fluorophenyl)-7-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one
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Structure
Formula
C30H24F7NO2
Molecular Weight
563.513
Canonical SMILES
C[C@@H](O[C@H]1CN2C(CC(=CC2=O)c2ccccc2)[C@@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
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InChI
InChI=1S/C30H24F7NO2/c1-17(20-11-22(29(32,33)34)15-23(12-20)30(35,36)37)40-26-16-38-25(28(26)19-7-9-24(31)10-8-19)13-21(14-27(38)39)18-5-3-2-4-6-18/h2-12,14-15,17,25-26,28H,13,16H2,1H3/t17-,25?,26+,28+/m1/s1
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InChIKey
QJPQOMYSGGNMMU-PTYIZKHBSA-N
Physicochemical Property
logP
7.7914
Rotatable Bonds
5
Heavy Atom Count
40
Polar Areas
29.54
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46884431
ChEMBL ID
CHEMBL1091043
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 0.93 nM
   TI
   LI
   LO
   TS
2
IC50 = 89.5 nM
   TI
   LI
   LO
   TS