General Information of the Compound
Compound ID
CP0421296
Compound Name
2-(((1R,2S,3S)-3-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentyl)(methyl)amino)-1-(pyrrolidin-1-yl)ethanone
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Structure
Formula
C28H31F7N2O2
Molecular Weight
560.554
Canonical SMILES
C[C@@H](O[C@H]1CC[C@H]([C@@H]1c1ccc(F)cc1)N(C)CC(=O)N1CCCC1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
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InChI
InChI=1S/C28H31F7N2O2/c1-17(19-13-20(27(30,31)32)15-21(14-19)28(33,34)35)39-24-10-9-23(26(24)18-5-7-22(29)8-6-18)36(2)16-25(38)37-11-3-4-12-37/h5-8,13-15,17,23-24,26H,3-4,9-12,16H2,1-2H3/t17-,23-,24+,26+/m1/s1
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InChIKey
XPVWAIADFDEAFW-NUYCEAJWSA-N
Physicochemical Property
logP
6.8099
Rotatable Bonds
7
Heavy Atom Count
39
Polar Areas
32.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44415808
ChEMBL ID
CHEMBL215975
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.43 nM
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   LI
   LO
   TS