General Information of the Compound
Compound ID
CP0419832
Compound Name
(2S)-2-amino-4-[[(2-amino-1,3-thiazol-5-yl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid
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Structure
Formula
C8H14N3O5PS
Molecular Weight
295.257
Canonical SMILES
N[C@@H](CCP(O)(=O)C(O)c1cnc(N)s1)C(O)=O
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InChI
InChI=1S/C8H14N3O5PS/c9-4(6(12)13)1-2-17(15,16)7(14)5-3-11-8(10)18-5/h3-4,7,14H,1-2,9H2,(H2,10,11)(H,12,13)(H,15,16)/t4-,7?/m0/s1
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InChIKey
VMDMUBRVPZAFNE-LRYVRFSDSA-N
Physicochemical Property
logP
-0.2114
Rotatable Bonds
6
Heavy Atom Count
18
Polar Areas
159.76
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
7
Complexity
18

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137661492
ChEMBL ID
CHEMBL4101796
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02199, Metabotropic glutamate receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 15000 nM
   TI
   LI
   LO
   TS
Protein ID: PT02744, Metabotropic glutamate receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT02739, Metabotropic glutamate receptor 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 28000 nM
   TI
   LI
   LO
   TS