General Information of the Compound
Compound ID
CP0418441
Compound Name
N-[2-(11-ethoxy-6,7-dihydro-5H-indolo[2,1-a][2]benzazepin-13-yl)ethyl]propanamide
    Show/Hide
Structure
Formula
C24H28N2O2
Molecular Weight
376.5
Canonical SMILES
CCOc1ccc2n3CCCc4ccccc4-c3c(CCNC(=O)CC)c2c1
    Show/Hide
InChI
InChI=1S/C24H28N2O2/c1-3-23(27)25-14-13-20-21-16-18(28-4-2)11-12-22(21)26-15-7-9-17-8-5-6-10-19(17)24(20)26/h5-6,8,10-12,16H,3-4,7,9,13-15H2,1-2H3,(H,25,27)
    Show/Hide
InChIKey
WUBIXKRGXDVHCT-UHFFFAOYSA-N
Physicochemical Property
logP
4.7219
Rotatable Bonds
6
Heavy Atom Count
28
Polar Areas
43.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 10714573
SID: 15749699
ChEMBL ID
CHEMBL276005
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01843, Melatonin receptor type 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
Ki = 269 nM
   TI
   LI
   LO
   TS
Protein ID: PT02174, Melatonin receptor type 1B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
Ki = 21.9 nM
   TI
   LI
   LO
   TS