General Information of the Compound
Compound ID
CP0417151
Compound Name
ethyl (3S,4S)-1-[2-(2,4-dioxo-1H-quinazolin-3-yl)ethyl]-4-(4-phenylphenyl)piperidine-3-carboxylate
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Structure
Formula
C30H31N3O4
Molecular Weight
497.595
Canonical SMILES
CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@@H]1c1ccc(cc1)-c1ccccc1
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InChI
InChI=1S/C30H31N3O4/c1-2-37-29(35)26-20-32(18-19-33-28(34)25-10-6-7-11-27(25)31-30(33)36)17-16-24(26)23-14-12-22(13-15-23)21-8-4-3-5-9-21/h3-15,24,26H,2,16-20H2,1H3,(H,31,36)/t24-,26-/m1/s1
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InChIKey
FHKFHTMCQMFFEY-AOYPEHQESA-N
Physicochemical Property
logP
4.0256
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
84.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118857837
ChEMBL ID
CHEMBL4212633
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00825, 5-hydroxytryptamine receptor 2A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00884, Sodium-dependent dopamine transporter
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01929, Synaptic vesicular amine transporter
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 3770 nM
   TI
   LI
   LO
   TS
3
Ki > 10000 nM
   TI
   LI
   LO
   TS