General Information of the Compound
Compound ID
CP0416188
Compound Name
tert-butyl (3R)-3-methyl-4-[5-[(1-methylsulfonylpiperidin-4-yl)methoxy]pyrimidin-2-yl]piperazine-1-carboxylate
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Structure
Formula
C21H35N5O5S
Molecular Weight
469.608
Canonical SMILES
C[C@@H]1CN(CCN1c1ncc(OCC2CCN(CC2)S(C)(=O)=O)cn1)C(=O)OC(C)(C)C
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InChI
InChI=1S/C21H35N5O5S/c1-16-14-24(20(27)31-21(2,3)4)10-11-26(16)19-22-12-18(13-23-19)30-15-17-6-8-25(9-7-17)32(5,28)29/h12-13,16-17H,6-11,14-15H2,1-5H3/t16-/m1/s1
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InChIKey
GRGQEEUXMIDNPJ-MRXNPFEDSA-N
Physicochemical Property
logP
1.9726
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
105.17
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 60155274
SID: 144086270
ChEMBL ID
CHEMBL2086668
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000107 HEK293S Homo sapiens (Human)  1
1
EC50 = 29 nM
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