General Information of the Compound
Compound ID
CP0415049
Compound Name
US10272079, Compound 142
    Show/Hide
Structure
Formula
C84H113Cl6N11O21S3
Molecular Weight
1921.803
Canonical SMILES
CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NC(CCC(=O)NCCOCCOCCNS(=O)(=O)c1cccc(c1)[C@@H]1CN(C)Cc2c(Cl)cc(Cl)cc12)(CCC(=O)NCCOCCOCCNS(=O)(=O)c1cccc(c1)[C@@H]1CN(C)Cc2c(Cl)cc(Cl)cc12)CCC(=O)NCCOCCOCCNS(=O)(=O)c1cccc(c1)[C@@H]1CN(C)Cc2c(Cl)cc(Cl)cc12
    Show/Hide
InChI
InChI=1S/C84H113Cl6N11O21S3/c1-98-47-67(64-41-58(85)44-73(88)70(64)50-98)55-8-5-11-61(38-55)123(111,112)94-23-29-120-35-32-117-26-20-91-78(105)14-17-84(97-83(110)101(4)53-76(103)81(108)82(109)77(104)54-102,18-15-79(106)92-21-27-118-33-36-121-30-24-95-124(113,114)62-12-6-9-56(39-62)68-48-99(2)51-71-65(68)42-59(86)45-74(71)89)19-16-80(107)93-22-28-119-34-37-122-31-25-96-125(115,116)63-13-7-10-57(40-63)69-49-100(3)52-72-66(69)43-60(87)46-75(72)90/h5-13,38-46,67-69,76-77,81-82,94-96,102-104,108-109H,14-37,47-54H2,1-4H3,(H,91,105)(H,92,106)(H,93,107)(H,97,110)/t67-,68-,69-,76-,77+,81+,82+/m0/s1
    Show/Hide
InChIKey
YILRXDDYBARNBH-MPNFEHKJSA-N
Physicochemical Property
logP
6.1791
Rotatable Bonds
52
Heavy Atom Count
125
Polar Areas
424.4
Hydrogen Bond Donor Count
12
Hydrogen Bond Acceptor Count
24
Complexity
125

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 118934057
ChEMBL ID
CHEMBL3895338
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04309, Sodium/hydrogen exchanger 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000422 OK Didelphis virginiana (North American opossum)  1
1
IC50 = 7.943 nM
   TI
   LI
   LO
   TS
Protein ID: PT03762, Sodium/hydrogen exchanger 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000422 OK Didelphis virginiana (North American opossum)  1
1
IC50 = 79.43 nM
   TI
   LI
   LO
   TS