General Information of the Compound
Compound ID
CP0415046
Compound Name
US10272079, Compound 48
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Structure
Formula
C62H86N8O16S2
Molecular Weight
1263.544
Canonical SMILES
OC(=O)CN(CCN(CC(O)=O)CC(=O)NCCOCCOCCNS(=O)(=O)c1ccc(O[C@@H]2[C@H](Cc3ccccc23)N2CCCCC2)cc1)CC(=O)NCCOCCOCCNS(=O)(=O)c1ccc(O[C@@H]2[C@H](Cc3ccccc23)N2CCCCC2)cc1
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InChI
InChI=1S/C62H86N8O16S2/c71-57(63-23-33-81-37-39-83-35-25-65-87(77,78)51-19-15-49(16-20-51)85-61-53-13-5-3-11-47(53)41-55(61)69-27-7-1-8-28-69)43-67(45-59(73)74)31-32-68(46-60(75)76)44-58(72)64-24-34-82-38-40-84-36-26-66-88(79,80)52-21-17-50(18-22-52)86-62-54-14-6-4-12-48(54)42-56(62)70-29-9-2-10-30-70/h3-6,11-22,55-56,61-62,65-66H,1-2,7-10,23-46H2,(H,63,71)(H,64,72)(H,73,74)(H,75,76)/t55-,56-,61-,62-/m0/s1
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InChIKey
VZFONDZSTSILTR-BPLYCLBXSA-N
Physicochemical Property
logP
3.0768
Rotatable Bonds
39
Heavy Atom Count
88
Polar Areas
293.48
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
18
Complexity
88

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118933965
ChEMBL ID
CHEMBL3897251
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04309, Sodium/hydrogen exchanger 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000422 OK Didelphis virginiana (North American opossum)  2
1
IC50 = 1.413 nM
   TI
   LI
   LO
   TS
2
IC50 = 28.18 nM
   TI
   LI
   LO
   TS
Protein ID: PT03762, Sodium/hydrogen exchanger 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000422 OK Didelphis virginiana (North American opossum)  2
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
2
IC50 = 79.43 nM
   TI
   LI
   LO
   TS