General Information of the Compound
Compound ID
CP0414690
Compound Name
(1R)-9-[(1,3-dimethylazetidin-3-yl)-methylamino]-1-methyl-8-(trifluoromethyl)-3,5-dihydro-1H-[1,2,4]triazino[3,4-c][1,4]benzoxazin-2-one
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Structure
Formula
C18H22F3N5O2
Molecular Weight
397.401
Canonical SMILES
C[C@H]1N2C(COc3cc(c(cc23)N(C)C2(C)CN(C)C2)C(F)(F)F)=NNC1=O
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InChI
InChI=1S/C18H22F3N5O2/c1-10-16(27)23-22-15-7-28-14-5-11(18(19,20)21)12(6-13(14)26(10)15)25(4)17(2)8-24(3)9-17/h5-6,10H,7-9H2,1-4H3,(H,23,27)/t10-/m1/s1
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InChIKey
LFKQXDRWWTVIRU-SNVBAGLBSA-N
Physicochemical Property
logP
1.8763
Rotatable Bonds
2
Heavy Atom Count
28
Polar Areas
60.41
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118720640
ChEMBL ID
CHEMBL3355115
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01127, Protein kinase C theta type
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000012 Sf21 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 700 nM
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