General Information of the Compound
Compound ID
CP0412625
Compound Name
2-[3-[4-[1-(benzenesulfonyl)indol-3-yl]-3,6-dihydro-2H-pyridin-1-yl]propoxy]benzamide
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Structure
Formula
C29H29N3O4S
Molecular Weight
515.635
Canonical SMILES
NC(=O)c1ccccc1OCCCN1CCC(=CC1)c1cn(c2ccccc12)S(=O)(=O)c1ccccc1
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InChI
InChI=1S/C29H29N3O4S/c30-29(33)25-12-5-7-14-28(25)36-20-8-17-31-18-15-22(16-19-31)26-21-32(27-13-6-4-11-24(26)27)37(34,35)23-9-2-1-3-10-23/h1-7,9-15,21H,8,16-20H2,(H2,30,33)
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InChIKey
GUZVTLAJXNRRJR-UHFFFAOYSA-N
Physicochemical Property
logP
4.5354
Rotatable Bonds
9
Heavy Atom Count
37
Polar Areas
94.63
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118731509
ChEMBL ID
CHEMBL3409244
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 33 nM
   TI
   LI
   LO
   TS
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 160 nM
   TI
   LI
   LO
   TS