General Information of the Compound
Compound ID
CP0412406
Compound Name
(2S,3S,4R,5R)-5-(6-(4-(2-(benzylamino)-2-oxoethoxy)phenylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
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Structure
Formula
C27H29N7O6
Molecular Weight
547.572
Canonical SMILES
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(Nc3ccc(OCC(=O)NCc4ccccc4)cc3)ncnc12
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InChI
InChI=1S/C27H29N7O6/c1-2-28-26(38)23-21(36)22(37)27(40-23)34-15-32-20-24(30-14-31-25(20)34)33-17-8-10-18(11-9-17)39-13-19(35)29-12-16-6-4-3-5-7-16/h3-11,14-15,21-23,27,36-37H,2,12-13H2,1H3,(H,28,38)(H,29,35)(H,30,31,33)/t21-,22+,23-,27+/m0/s1
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InChIKey
QHELZZNMVAGGIB-NBCVKUGOSA-N
Physicochemical Property
logP
1.0204
Rotatable Bonds
10
Heavy Atom Count
40
Polar Areas
172.75
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
11
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44423824
ChEMBL ID
CHEMBL375501
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 20.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 150 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 82.7 nM
   TI
   LI
   LO
   TS