General Information of the Compound
Compound ID
CP0409265
Compound Name
(R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl)-2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamide
    Show/Hide
Structure
Formula
C21H19N5O4
Molecular Weight
405.414
Canonical SMILES
CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4ccccc4[nH]c3=O)cc2C1
    Show/Hide
InChI
InChI=1S/C21H19N5O4/c1-25-19(29)24-18(28)21(25)9-12-6-7-14(8-13(12)10-21)22-17(27)11-26-16-5-3-2-4-15(16)23-20(26)30/h2-8H,9-11H2,1H3,(H,22,27)(H,23,30)(H,24,28,29)/t21-/m1/s1
    Show/Hide
InChIKey
CGVMXRNLZJBUJV-OAQYLSRUSA-N
Physicochemical Property
logP
0.9873
Rotatable Bonds
3
Heavy Atom Count
30
Polar Areas
116.3
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44420228
ChEMBL ID
CHEMBL221009
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  4
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
2
IC50 = 1200 nM
   TI
   LI
   LO
   TS
3
Ki = 38 nM
   TI
   LI
   LO
   TS
4
Ki = 43 nM
   TI
   LI
   LO
   TS
CL000748 NAL1A clone C4E10 Mus musculus (Mouse)  1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS