General Information of the Compound
Compound ID
CP0408235
Compound Name
(R)-2-(4-ethylphenyl)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3-yl)thieno[2,3-d]pyridazin-7(6H)-one
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Structure
Formula
C24H25N5OS
Molecular Weight
431.565
Canonical SMILES
CCc1ccc(cc1)-c1cc2cnn(-c3ccc(nc3)N3CC[C@H](C3)NC)c(=O)c2s1
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InChI
InChI=1S/C24H25N5OS/c1-3-16-4-6-17(7-5-16)21-12-18-13-27-29(24(30)23(18)31-21)20-8-9-22(26-14-20)28-11-10-19(15-28)25-2/h4-9,12-14,19,25H,3,10-11,15H2,1-2H3/t19-/m1/s1
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InChIKey
DAWVIISZSJSPPE-LJQANCHMSA-N
Physicochemical Property
logP
3.8697
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
63.05
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11626170
SID: 16729198
ChEMBL ID
CHEMBL211340
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01388, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 2.6 nM
   TI
   LI
   LO
   TS