General Information of the Compound
Compound ID
CP0407994
Compound Name
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-(6-(4-(2-(4-methoxyphenylamino)-2-oxoethoxy)phenylamino)-9H-purin-9-yl)-tetrahydrofuran-2-carboxamide
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Structure
Formula
C27H29N7O7
Molecular Weight
563.571
Canonical SMILES
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(Nc3ccc(OCC(=O)Nc4ccc(OC)cc4)cc3)ncnc12
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InChI
InChI=1S/C27H29N7O7/c1-3-28-26(38)23-21(36)22(37)27(41-23)34-14-31-20-24(29-13-30-25(20)34)33-16-6-10-18(11-7-16)40-12-19(35)32-15-4-8-17(39-2)9-5-15/h4-11,13-14,21-23,27,36-37H,3,12H2,1-2H3,(H,28,38)(H,32,35)(H,29,30,33)/t21-,22+,23-,27+/m0/s1
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InChIKey
LBUWUFSXGXBBAT-NBCVKUGOSA-N
Physicochemical Property
logP
1.3513
Rotatable Bonds
10
Heavy Atom Count
41
Polar Areas
181.98
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
12
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44423817
ChEMBL ID
CHEMBL226243
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4.7 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 32.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 25.3 nM
   TI
   LI
   LO
   TS