General Information of the Compound
Compound ID
CP0407220
Compound Name
(5S)-5-[[[(1R,2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylcyclopentyl]-methylamino]methyl]pyrrolidin-2-one
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Structure
Formula
C26H28F6N2O2
Molecular Weight
514.51
Canonical SMILES
CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@H]1c1ccccc1
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InChI
InChI=1S/C26H28F6N2O2/c1-34(14-20-7-10-23(35)33-20)21-8-9-22(24(21)17-5-3-2-4-6-17)36-15-16-11-18(25(27,28)29)13-19(12-16)26(30,31)32/h2-6,11-13,20-22,24H,7-10,14-15H2,1H3,(H,33,35)/t20-,21+,22-,24-/m0/s1
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InChIKey
FLLDRPOJCLGUHA-KHUIQGCPSA-N
Physicochemical Property
logP
5.766
Rotatable Bonds
7
Heavy Atom Count
36
Polar Areas
41.57
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44415404
ChEMBL ID
CHEMBL212931
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.81 nM
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