General Information of the Compound
Compound ID
CP0407113
Compound Name
N-(7-benzyl-5-piperidin-1-yl-3,6,8,9-tetrahydropyrazolo[3,4-c][2,7]naphthyridin-1-yl)cyclopentanecarboxamide
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Structure
Formula
C27H34N6O
Molecular Weight
458.61
Canonical SMILES
O=C(Nc1n[nH]c2nc(N3CCCCC3)c3CN(Cc4ccccc4)CCc3c12)C1CCCC1
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InChI
InChI=1S/C27H34N6O/c34-27(20-11-5-6-12-20)29-25-23-21-13-16-32(17-19-9-3-1-4-10-19)18-22(21)26(28-24(23)30-31-25)33-14-7-2-8-15-33/h1,3-4,9-10,20H,2,5-8,11-18H2,(H2,28,29,30,31,34)
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InChIKey
LHBIEQDJQZBDIU-UHFFFAOYSA-N
Physicochemical Property
logP
4.6352
Rotatable Bonds
5
Heavy Atom Count
34
Polar Areas
77.15
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46888019
ChEMBL ID
CHEMBL1098838
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05288, Bombesin receptor subtype-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000866 HEK293 AequoScreen Homo sapiens (Human)  1
1
EC50 = 413 nM
   TI
   LI
   LO
   TS
Protein ID: PT01996, Bombesin receptor subtype-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000866 HEK293 AequoScreen Homo sapiens (Human)  1
1
EC50 = 704 nM
   TI
   LI
   LO
   TS