General Information of the Compound
Compound ID
CP0406004
Compound Name
N-[8-(furan-2-yl)-9-methylpurin-6-yl]-2-(4-phenylmethoxyphenyl)acetamide
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Structure
Formula
C25H21N5O3
Molecular Weight
439.475
Canonical SMILES
Cn1c(nc2c(NC(=O)Cc3ccc(OCc4ccccc4)cc3)ncnc12)-c1ccco1
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InChI
InChI=1S/C25H21N5O3/c1-30-24(20-8-5-13-32-20)29-22-23(26-16-27-25(22)30)28-21(31)14-17-9-11-19(12-10-17)33-15-18-6-3-2-4-7-18/h2-13,16H,14-15H2,1H3,(H,26,27,28,31)
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InChIKey
QVZCNOLUHYEZHK-UHFFFAOYSA-N
Physicochemical Property
logP
4.3835
Rotatable Bonds
7
Heavy Atom Count
33
Polar Areas
95.07
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 76313600
ChEMBL ID
CHEMBL3087711
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 438 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 50 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 5070 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 5233 nM
   TI
   LI
   LO
   TS