General Information of the Compound
Compound ID
CP0405996
Compound Name
(R)-2-[(2S,3S)-3-{4-[2-Ethyl-5-(2-fluoro-benzyl)-2H-pyrazol-3-yl]-piperidin-1-ylmethyl}-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3,3-dimethyl-butyric acid
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Structure
Formula
C34H44F2N4O2
Molecular Weight
578.748
Canonical SMILES
CCn1nc(Cc2ccccc2F)cc1C1CCN(C[C@H]2CN(C[C@@H]2c2cccc(F)c2)[C@@H](C(O)=O)C(C)(C)C)CC1
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InChI
InChI=1S/C34H44F2N4O2/c1-5-40-31(19-28(37-40)18-25-9-6-7-12-30(25)36)23-13-15-38(16-14-23)20-26-21-39(32(33(41)42)34(2,3)4)22-29(26)24-10-8-11-27(35)17-24/h6-12,17,19,23,26,29,32H,5,13-16,18,20-22H2,1-4H3,(H,41,42)/t26-,29+,32-/m0/s1
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InChIKey
AMEANAGWRYNMDA-SBAONXBNSA-N
Physicochemical Property
logP
6.1663
Rotatable Bonds
9
Heavy Atom Count
42
Polar Areas
61.6
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44385583
ChEMBL ID
CHEMBL177071
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.5 nM
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   LI
   LO
   TS