General Information of the Compound
Compound ID
CP0405290
Compound Name
6-methoxy-7-(4-methylpiperazin-1-yl)-1-(naphthalen-2-ylsulfonyl)-2,3-dihydroquinolin-4(1H)-one
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Structure
Formula
C25H27N3O4S
Molecular Weight
465.575
Canonical SMILES
COc1cc2C(=O)CCN(c2cc1N1CCN(C)CC1)S(=O)(=O)c1ccc2ccccc2c1
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InChI
InChI=1S/C25H27N3O4S/c1-26-11-13-27(14-12-26)23-17-22-21(16-25(23)32-2)24(29)9-10-28(22)33(30,31)20-8-7-18-5-3-4-6-19(18)15-20/h3-8,15-17H,9-14H2,1-2H3
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InChIKey
AMYPFPOCEWHTIS-UHFFFAOYSA-N
Physicochemical Property
logP
3.3819
Rotatable Bonds
4
Heavy Atom Count
33
Polar Areas
70.16
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53321318
SID: 136365600
ChEMBL ID
CHEMBL1642121
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 165 nM
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