General Information of the Compound
Compound ID
CP0405285
Compound Name
9-(2-(4-chlorophenoxy)ethyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[1,2-a]purine-2,4(1H,3H)-dione
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Structure
Formula
C18H20ClN5O3
Molecular Weight
389.843
Canonical SMILES
Cn1c2nc3N(CCOc4ccc(Cl)cc4)CCCn3c2c(=O)n(C)c1=O
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InChI
InChI=1S/C18H20ClN5O3/c1-21-15-14(16(25)22(2)18(21)26)24-9-3-8-23(17(24)20-15)10-11-27-13-6-4-12(19)5-7-13/h4-7H,3,8-11H2,1-2H3
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InChIKey
PFBOTKATPZUABQ-UHFFFAOYSA-N
Physicochemical Property
logP
1.3762
Rotatable Bonds
4
Heavy Atom Count
27
Polar Areas
74.29
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11003653
SID: 16063890
ChEMBL ID
CHEMBL391718
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10000 nM
   TI
   LI
   LO
   TS