General Information of the Compound
Compound ID
CP0404071
Compound Name
(E)-1-[1-(1-methylimidazol-2-yl)sulfonyl-2-phenylindol-3-yl]-N-(4-methylpiperazin-1-yl)methanimine
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Structure
Formula
C24H26N6O2S
Molecular Weight
462.579
Canonical SMILES
CN1CCN(CC1)\N=C\c1c(-c2ccccc2)n(c2ccccc12)S(=O)(=O)c1nccn1C
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InChI
InChI=1S/C24H26N6O2S/c1-27-14-16-29(17-15-27)26-18-21-20-10-6-7-11-22(20)30(23(21)19-8-4-3-5-9-19)33(31,32)24-25-12-13-28(24)2/h3-13,18H,14-17H2,1-2H3/b26-18+
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InChIKey
JYGZYVXCQNPUHD-NLRVBDNBSA-N
Physicochemical Property
logP
2.8601
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
75.73
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73347610
ChEMBL ID
CHEMBL2414705
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 3600 nM
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