General Information of the Compound
Compound ID
CP0402605
Compound Name
5-(Dimethylamino)-N-(8-{4-[5-({[5-(dimethylamino)-1-naphthyl]-sulfonyl}amino)-2-methoxyphenyl]piperazin-1-yl}octyl)naphthalene-1-sulfonamide
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Structure
Formula
C43H56N6O5S2
Molecular Weight
801.092
Canonical SMILES
COc1ccc(NS(=O)(=O)c2cccc3c(cccc23)N(C)C)cc1N1CCN(CCCCCCCCNS(=O)(=O)c2cccc3c(cccc23)N(C)C)CC1
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InChI
InChI=1S/C43H56N6O5S2/c1-46(2)38-20-12-18-36-34(38)16-14-22-42(36)55(50,51)44-26-10-8-6-7-9-11-27-48-28-30-49(31-29-48)40-32-33(24-25-41(40)54-5)45-56(52,53)43-23-15-17-35-37(43)19-13-21-39(35)47(3)4/h12-25,32,44-45H,6-11,26-31H2,1-5H3
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InChIKey
YRADJILHDILUQA-UHFFFAOYSA-N
Physicochemical Property
logP
7.3755
Rotatable Bonds
18
Heavy Atom Count
56
Polar Areas
114.53
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
56

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49781469
SID: 103055547
ChEMBL ID
CHEMBL1256259
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 194 nM
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