General Information of the Compound
Compound ID
CP0401279
Compound Name
3,3-dimethyl-5-m-tolyl-2,3-dihydro-1H-inden-1-one
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Synonyms
3,3-dimethyl-5-m-tolyl-2,3-dihydro-1H-inden-1-one
BDBM50299884
CHEMBL566982
IQXQUXAACBOTRO-UHFFFAOYSA-N
SCHEMBL4421269
ZINC45245855
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Structure
Formula
C18H18O
Molecular Weight
250.341
Canonical SMILES
Cc1cccc(c1)-c1ccc2C(=O)CC(C)(C)c2c1
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InChI
InChI=1S/C18H18O/c1-12-5-4-6-13(9-12)14-7-8-15-16(10-14)18(2,3)11-17(15)19/h4-10H,11H2,1-3H3
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InChIKey
IQXQUXAACBOTRO-UHFFFAOYSA-N
Physicochemical Property
logP
4.52602
Rotatable Bonds
1
Heavy Atom Count
19
Polar Areas
17.07
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
1
Complexity
19

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45483822
ChEMBL ID
CHEMBL566982
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 225 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 3,3-dimethyl-5-m-tolyl-2,3-dihydro-1H-inden-1-one )
Drug Name 3,3-dimethyl-5-m-tolyl-2,3-dihydro-1H-inden-1-one
Target(s)
Progesterone receptor (PGR)
Inhibitor