General Information of the Compound
Compound ID
CP0400203
Compound Name
7-benzyl-5-(4-fluoropiperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-amine
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Structure
Formula
C21H25FN6
Molecular Weight
380.471
Canonical SMILES
Nc1n[nH]c2nc(N3CCC(F)CC3)c3CN(Cc4ccccc4)CCc3c12
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InChI
InChI=1S/C21H25FN6/c22-15-6-10-28(11-7-15)21-17-13-27(12-14-4-2-1-3-5-14)9-8-16(17)18-19(23)25-26-20(18)24-21/h1-5,15H,6-13H2,(H3,23,24,25,26)
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InChIKey
UMVHTJBYCVSGRZ-UHFFFAOYSA-N
Physicochemical Property
logP
3.0367
Rotatable Bonds
3
Heavy Atom Count
28
Polar Areas
74.07
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46887824
ChEMBL ID
CHEMBL1098097
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05288, Bombesin receptor subtype-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000866 HEK293 AequoScreen Homo sapiens (Human)  1
1
EC50 = 481 nM
   TI
   LI
   LO
   TS
Protein ID: PT01996, Bombesin receptor subtype-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000866 HEK293 AequoScreen Homo sapiens (Human)  1
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS