General Information of the Compound
Compound ID
CP0399732
Compound Name
N-[2-(4-chlorophenyl)ethyl]-N-(1,4-dioxaspiro[4.5]decan-8-yl)-1,2-benzoxazole-3-carboxamide
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Structure
Formula
C24H25ClN2O4
Molecular Weight
440.927
Canonical SMILES
Clc1ccc(CCN(C2CCC3(CC2)OCCO3)C(=O)c2noc3ccccc23)cc1
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InChI
InChI=1S/C24H25ClN2O4/c25-18-7-5-17(6-8-18)11-14-27(19-9-12-24(13-10-19)29-15-16-30-24)23(28)22-20-3-1-2-4-21(20)31-26-22/h1-8,19H,9-16H2
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InChIKey
TXJDQMSODATXQW-UHFFFAOYSA-N
Physicochemical Property
logP
4.8518
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
64.8
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44589781
ChEMBL ID
CHEMBL519048
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02772, C5a anaphylatoxin chemotactic receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 > 1000 nM
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