General Information of the Compound
Compound ID
CP0399664
Compound Name
(2S,3S,4R,5R)-5-[6-amino-2-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethylamino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
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Structure
Formula
C27H39N9O6
Molecular Weight
585.666
Canonical SMILES
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(NCCN3CCN(CC3)c3ccc(OCCOC)cc3)nc12
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InChI
InChI=1S/C27H39N9O6/c1-3-29-25(39)22-20(37)21(38)26(42-22)36-16-31-19-23(28)32-27(33-24(19)36)30-8-9-34-10-12-35(13-11-34)17-4-6-18(7-5-17)41-15-14-40-2/h4-7,16,20-22,26,37-38H,3,8-15H2,1-2H3,(H,29,39)(H3,28,30,32,33)/t20-,21+,22-,26+/m0/s1
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InChIKey
UFKWKIGRCPIVAD-IMIIHFCZSA-N
Physicochemical Property
logP
-0.5769
Rotatable Bonds
12
Heavy Atom Count
42
Polar Areas
185.38
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
14
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118734352
ChEMBL ID
CHEMBL3416787
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 84 nM
   TI
   LI
   LO
   TS
2
Ki = 56 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2195 nM
   TI
   LI
   LO
   TS