General Information of the Compound
Compound ID
CP0399628
Compound Name
(2S)-2-(1H-indazol-5-ylmethylamino)-4-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]-1-(4-piperidin-1-ylpiperidin-1-yl)butane-1,4-dione
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Structure
Formula
C35H46N8O3
Molecular Weight
626.806
Canonical SMILES
O=C(C[C@H](NCc1ccc2[nH]ncc2c1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O
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InChI
InChI=1S/C35H46N8O3/c44-33(41-16-12-29(13-17-41)43-24-26-6-2-3-7-30(26)38-35(43)46)21-32(36-22-25-8-9-31-27(20-25)23-37-39-31)34(45)42-18-10-28(11-19-42)40-14-4-1-5-15-40/h2-3,6-9,20,23,28-29,32,36H,1,4-5,10-19,21-22,24H2,(H,37,39)(H,38,46)/t32-/m0/s1
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InChIKey
ZJTUGHFBQAMQEE-YTTGMZPUSA-N
Physicochemical Property
logP
3.9268
Rotatable Bonds
8
Heavy Atom Count
46
Polar Areas
116.91
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 58864453
ChEMBL ID
CHEMBL2018356
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
2
IC50 = 300 nM
   TI
   LI
   LO
   TS