General Information of the Compound
Compound ID
CP0399503
Compound Name
(2S,3S,4R,5R)-5-(6-(4-(2-(4-methoxybenzylamino)-2-oxoethoxy)phenylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
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Structure
Formula
C28H31N7O7
Molecular Weight
577.598
Canonical SMILES
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(Nc3ccc(OCC(=O)NCc4ccc(OC)cc4)cc3)ncnc12
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InChI
InChI=1S/C28H31N7O7/c1-3-29-27(39)24-22(37)23(38)28(42-24)35-15-33-21-25(31-14-32-26(21)35)34-17-6-10-19(11-7-17)41-13-20(36)30-12-16-4-8-18(40-2)9-5-16/h4-11,14-15,22-24,28,37-38H,3,12-13H2,1-2H3,(H,29,39)(H,30,36)(H,31,32,34)/t22-,23+,24-,28+/m0/s1
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InChIKey
GIHMDZYJOCZIMV-NLJXWPIHSA-N
Physicochemical Property
logP
1.029
Rotatable Bonds
11
Heavy Atom Count
42
Polar Areas
181.98
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
12
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44423825
ChEMBL ID
CHEMBL226304
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 28.3 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 240 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 65.4 nM
   TI
   LI
   LO
   TS