General Information of the Compound
Compound ID
CP0399501
Compound Name
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-(6-(4-(2-(4-morpholinophenylamino)-2-oxoethoxy)phenylamino)-9H-purin-9-yl)-tetrahydrofuran-2-carboxamide
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Structure
Formula
C30H34N8O7
Molecular Weight
618.651
Canonical SMILES
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(Nc3ccc(OCC(=O)Nc4ccc(cc4)N4CCOCC4)cc3)ncnc12
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InChI
InChI=1S/C30H34N8O7/c1-2-31-29(42)26-24(40)25(41)30(45-26)38-17-34-23-27(32-16-33-28(23)38)36-19-5-9-21(10-6-19)44-15-22(39)35-18-3-7-20(8-4-18)37-11-13-43-14-12-37/h3-10,16-17,24-26,30,40-41H,2,11-15H2,1H3,(H,31,42)(H,35,39)(H,32,33,36)/t24-,25+,26-,30+/m0/s1
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InChIKey
MAIPEOCRMBVJIO-YRIIQKNPSA-N
Physicochemical Property
logP
1.1793
Rotatable Bonds
10
Heavy Atom Count
45
Polar Areas
185.22
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
13
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44423822
ChEMBL ID
CHEMBL226303
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 77.5 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 300 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 320 nM
   TI
   LI
   LO
   TS