General Information of the Compound
Compound ID
CP0398681
Compound Name
7-[4-[4-[1-(benzenesulfonyl)indol-3-yl]-3,6-dihydro-2H-pyridin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
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Structure
Formula
C32H33N3O4S
Molecular Weight
555.7
Canonical SMILES
O=C1CCc2ccc(OCCCCN3CCC(=CC3)c3cn(c4ccccc34)S(=O)(=O)c3ccccc3)cc2N1
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InChI
InChI=1S/C32H33N3O4S/c36-32-15-13-25-12-14-26(22-30(25)33-32)39-21-7-6-18-34-19-16-24(17-20-34)29-23-35(31-11-5-4-10-28(29)31)40(37,38)27-8-2-1-3-9-27/h1-5,8-12,14,16,22-23H,6-7,13,15,17-21H2,(H,33,36)
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InChIKey
POTCTIWPEKKBBZ-UHFFFAOYSA-N
Physicochemical Property
logP
5.7113
Rotatable Bonds
9
Heavy Atom Count
40
Polar Areas
80.64
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118731503
ChEMBL ID
CHEMBL3409233
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 52 nM
   TI
   LI
   LO
   TS
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 40 nM
   TI
   LI
   LO
   TS