General Information of the Compound
Compound ID
CP0398591
Compound Name
CHEMBL524050
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Formula
C32H43N5O
Molecular Weight
513.73
Canonical SMILES
CC(C)NC(=O)N1CCC(CCN2[C@H]3CC[C@@H]2C[C@@H](C3)n2c(C)nc3ccccc23)(CC1)c1ccccc1
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InChI
InChI=1S/C32H43N5O/c1-23(2)33-31(38)35-18-15-32(16-19-35,25-9-5-4-6-10-25)17-20-36-26-13-14-27(36)22-28(21-26)37-24(3)34-29-11-7-8-12-30(29)37/h4-12,23,26-28H,13-22H2,1-3H3,(H,33,38)/t26-,27+,28+
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InChIKey
DPTAFEGODXQGLH-KUMHGWDASA-N
Physicochemical Property
logP
6.05452
Rotatable Bonds
6
Heavy Atom Count
38
Polar Areas
53.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL524050
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 4 nM
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