General Information of the Compound
Compound ID
CP0397669
Compound Name
1-Aza-bicyclo[2.2.2]octane-4-carboxylic acid [(S)-4-(3,5-bis-trifluoromethyl-phenyl)-1-(1H-indol-3-ylmethyl)-2-oxo-butyl]-amide
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Structure
Formula
C29H29F6N3O2
Molecular Weight
565.558
Canonical SMILES
FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C23CCN(CC2)CC3)cc(c1)C(F)(F)F
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InChI
InChI=1S/C29H29F6N3O2/c30-28(31,32)20-13-18(14-21(16-20)29(33,34)35)5-6-25(39)24(15-19-17-36-23-4-2-1-3-22(19)23)37-26(40)27-7-10-38(11-8-27)12-9-27/h1-4,13-14,16-17,24,36H,5-12,15H2,(H,37,40)/t24-/m0/s1
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InChIKey
MITDQFYCYRHNBC-DEOSSOPVSA-N
Physicochemical Property
logP
5.9206
Rotatable Bonds
8
Heavy Atom Count
40
Polar Areas
65.2
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9938657
SID: 15037209
ChEMBL ID
CHEMBL174038
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  3
1
IC50 = 0.9 nM
   TI
   LI
   LO
   TS
2
IC50 = 1 nM
   TI
   LI
   LO
   TS
3
IC50 = 8 nM
   TI
   LI
   LO
   TS