General Information of the Compound
Compound ID
CP0397158
Compound Name
N-[5-[4-amino-6-(dimethylamino)-1,3,5-triazine-2-carbonyl]-4-phenyl-1,3-thiazol-2-yl]-4-methoxybenzamide
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Structure
Formula
C23H21N7O3S
Molecular Weight
475.534
Canonical SMILES
COc1ccc(cc1)C(=O)Nc1nc(c(s1)C(=O)c1nc(N)nc(n1)N(C)C)-c1ccccc1
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InChI
InChI=1S/C23H21N7O3S/c1-30(2)22-27-19(26-21(24)29-22)17(31)18-16(13-7-5-4-6-8-13)25-23(34-18)28-20(32)14-9-11-15(33-3)12-10-14/h4-12H,1-3H3,(H,25,28,32)(H2,24,26,27,29)
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InChIKey
PMVWRANITNYUHW-UHFFFAOYSA-N
Physicochemical Property
logP
3.1352
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
136.22
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73348946
ChEMBL ID
CHEMBL2391842
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10400 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2010 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2640 nM
   TI
   LI
   LO
   TS